Assay Detail
Binding
CHEMBL3371193
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Inhibition of human recombinant 5HT6 receptor expressed in CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.93 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431298 | — | — | 1 | 8.70 |
| CHEMBL23038 | — | — | 1 | 8.49 |
| CHEMBL361213 | — | — | 1 | 8.07 |
| CHEMBL292759 | — | — | 1 | 7.80 |
| CHEMBL179814 | — | — | 1 | 7.62 |
| CHEMBL367088 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431298 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL23038 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL361213 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL292759 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL179814 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL367088 | — | IC50 | = | 135.0 | nM | 6.87 |