Assay Detail
Binding
CHEMBL3371272
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Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 by fluorescent densitometry
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.61 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319580 | — | — | 1 | 8.22 |
| CHEMBL3319587 | — | — | 1 | 8.00 |
| CHEMBL3319585 | — | — | 1 | 7.90 |
| CHEMBL3319586 | — | — | 1 | 7.85 |
| CHEMBL3319578 | — | — | 1 | 7.84 |
| CHEMBL3319478 | — | — | 1 | 7.70 |
| CHEMBL3319588 | — | — | 1 | 7.37 |
| CHEMBL3237875 | — | — | 1 | 7.27 |
| CHEMBL3319484 | — | — | 1 | 7.10 |
| CHEMBL3319479 | — | — | 1 | 7.01 |
| CHEMBL3319582 | — | — | 1 | 6.98 |
| CHEMBL3319583 | — | — | 1 | 6.94 |
| CHEMBL3319584 | — | — | 1 | 6.80 |
| CHEMBL3319482 | — | — | 1 | 6.64 |
| CHEMBL3319481 | — | — | 1 | 6.54 |
| CHEMBL3319581 | — | — | 1 | 6.08 |
| CHEMBL3319480 | — | — | 1 | 5.75 |
| CHEMBL3319577 | — | — | 1 | 5.72 |
| CHEMBL3319483 | — | — | 1 | 5.34 |
| CHEMBL3319579 | — | — | 1 | 5.26 |
| CHEMBL3319589 | — | — | 1 | 4.85 |
| CHEMBL3319591 | — | — | 1 | 4.60 |
| CHEMBL3319592 | — | — | 1 | 4.21 |
| CHEMBL3319590 | — | — | 1 | - |
| CHEMBL3319477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319580 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3319587 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL3319585 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL3319586 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3319578 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL3319478 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3319588 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3237875 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3319484 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3319479 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3319582 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3319583 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3319584 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL3319482 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL3319481 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL3319581 | — | IC50 | = | 827.0 | nM | 6.08 |
| CHEMBL3319480 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3319577 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3319483 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3319579 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3319589 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3319591 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3319592 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL3319590 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3319477 | — | IC50 | > | 50000.0 | nM | - |