Assay Detail
Functional
CHEMBL3371613
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Antiviral activity against HCV genotype 1a infected in human HuH7 cells by luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent bisimidazole-based HCV NS5A inhibitors bearing annulated tricyclic motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 9.05 | 10.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360471 | — | — | 1 | 10.36 |
| CHEMBL3360477 | — | — | 1 | 10.19 |
| CHEMBL3360476 | — | — | 1 | 10.14 |
| CHEMBL3360479 | — | — | 1 | 10.06 |
| CHEMBL3360462 | — | — | 1 | 10.01 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 9.85 |
| CHEMBL3360472 | — | — | 1 | 9.76 |
| CHEMBL3121854 | — | — | 1 | 9.60 |
| CHEMBL3360465 | — | — | 1 | 9.40 |
| CHEMBL3121855 | — | — | 1 | 9.35 |
| CHEMBL3360473 | — | — | 1 | 9.22 |
| CHEMBL3121856 | — | — | 1 | 8.94 |
| CHEMBL3360464 | — | — | 1 | 8.74 |
| CHEMBL3360468 | — | — | 1 | 8.70 |
| CHEMBL3360474 | — | — | 1 | 8.60 |
| CHEMBL3360467 | — | — | 1 | 8.52 |
| CHEMBL3360475 | — | — | 1 | 8.47 |
| CHEMBL3360461 | — | — | 1 | 8.32 |
| CHEMBL3360460 | — | — | 1 | 8.13 |
| CHEMBL3360470 | — | — | 1 | 8.11 |
| CHEMBL3360466 | — | — | 1 | 8.05 |
| CHEMBL3360478 | — | — | 1 | 7.96 |
| CHEMBL3360469 | — | — | 1 | 7.78 |
| CHEMBL3360459 | — | — | 1 | - |
| CHEMBL3360463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360471 | — | EC50 | = | 0.044 | nM | 10.36 |
| CHEMBL3360477 | — | EC50 | = | 0.065 | nM | 10.19 |
| CHEMBL3360476 | — | EC50 | = | 0.073 | nM | 10.14 |
| CHEMBL3360479 | — | EC50 | = | 0.088 | nM | 10.06 |
| CHEMBL3360462 | — | EC50 | = | 0.098 | nM | 10.01 |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3360472 | — | EC50 | = | 0.173 | nM | 9.76 |
| CHEMBL3121854 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3360465 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3121855 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL3360473 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3121856 | — | EC50 | = | 1.14 | nM | 8.94 |
| CHEMBL3360464 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3360468 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3360474 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3360467 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3360475 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3360461 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3360460 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3360470 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3360466 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3360478 | — | EC50 | = | 11.1 | nM | 7.96 |
| CHEMBL3360469 | — | EC50 | = | 16.5 | nM | 7.78 |
| CHEMBL3360459 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL3360463 | — | EC50 | > | 100.0 | nM | - |