Assay Detail
Binding
CHEMBL3371729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human caspase-7 activity using Ac-DEVD-AMC as substrate preincubated for 10 mins by fluorescence assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.77 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360048 | — | — | 1 | 7.29 |
| CHEMBL3360047 | — | — | 1 | 7.27 |
| CHEMBL3360059 | — | — | 1 | 7.25 |
| CHEMBL3360051 | — | — | 1 | 7.22 |
| CHEMBL3360046 | — | — | 1 | 7.20 |
| CHEMBL3360053 | — | — | 1 | 7.14 |
| CHEMBL3360045 | — | — | 1 | 7.14 |
| CHEMBL3360056 | — | — | 1 | 7.13 |
| CHEMBL3360050 | — | — | 1 | 7.11 |
| CHEMBL3360049 | — | — | 1 | 7.06 |
| CHEMBL3360055 | — | — | 1 | 7.01 |
| CHEMBL3360057 | — | — | 1 | 7.00 |
| CHEMBL3360044 | — | — | 1 | 6.96 |
| CHEMBL3360043 | — | — | 1 | 6.95 |
| CHEMBL3360060 | — | — | 1 | 6.94 |
| CHEMBL3360061 | — | — | 1 | 6.94 |
| CHEMBL3360035 | — | — | 1 | 6.91 |
| CHEMBL3360038 | — | — | 1 | 6.84 |
| CHEMBL417149 | — | — | 1 | 6.81 |
| CHEMBL3360052 | — | — | 1 | 6.80 |
| CHEMBL3233630 | — | — | 1 | 6.79 |
| CHEMBL3360054 | — | — | 1 | 6.78 |
| CHEMBL3360030 | — | — | 1 | 6.74 |
| CHEMBL3360031 | — | — | 1 | 6.74 |
| CHEMBL3360063 | — | — | 1 | 6.73 |
| CHEMBL3360042 | — | — | 1 | 6.70 |
| CHEMBL3360032 | — | — | 1 | 6.68 |
| CHEMBL3360034 | — | — | 1 | 6.67 |
| CHEMBL3360033 | — | — | 1 | 6.67 |
| CHEMBL3360028 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360048 | — | IC50 | = | 51.9 | nM | 7.29 |
| CHEMBL3360047 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3360059 | — | IC50 | = | 56.7 | nM | 7.25 |
| CHEMBL3360051 | — | IC50 | = | 59.7 | nM | 7.22 |
| CHEMBL3360046 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL3360053 | — | IC50 | = | 72.7 | nM | 7.14 |
| CHEMBL3360045 | — | IC50 | = | 72.5 | nM | 7.14 |
| CHEMBL3360056 | — | IC50 | = | 74.9 | nM | 7.13 |
| CHEMBL3360050 | — | IC50 | = | 78.4 | nM | 7.11 |
| CHEMBL3360049 | — | IC50 | = | 86.9 | nM | 7.06 |
| CHEMBL3360055 | — | IC50 | = | 97.9 | nM | 7.01 |
| CHEMBL3360057 | — | IC50 | = | 100.9 | nM | 7.00 |
| CHEMBL3360044 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3360043 | — | IC50 | = | 111.9 | nM | 6.95 |
| CHEMBL3360061 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3360060 | — | IC50 | = | 115.1 | nM | 6.94 |
| CHEMBL3360035 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL3360038 | — | IC50 | = | 144.9 | nM | 6.84 |
| CHEMBL417149 | — | IC50 | = | 155.2 | nM | 6.81 |
| CHEMBL3360052 | — | IC50 | = | 158.2 | nM | 6.80 |
| CHEMBL3233630 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3360054 | — | IC50 | = | 166.3 | nM | 6.78 |
| CHEMBL3360030 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL3360031 | — | IC50 | = | 182.3 | nM | 6.74 |
| CHEMBL3360063 | — | IC50 | = | 185.1 | nM | 6.73 |
| CHEMBL3360042 | — | IC50 | = | 198.3 | nM | 6.70 |
| CHEMBL3360032 | — | IC50 | = | 207.2 | nM | 6.68 |
| CHEMBL3360034 | — | IC50 | = | 213.3 | nM | 6.67 |
| CHEMBL3360033 | — | IC50 | = | 211.2 | nM | 6.67 |
| CHEMBL3360028 | — | IC50 | = | 268.7 | nM | 6.57 |
| CHEMBL3360062 | — | IC50 | = | 296.7 | nM | 6.53 |
| CHEMBL3360041 | — | IC50 | = | 330.1 | nM | 6.48 |
| CHEMBL3360029 | — | IC50 | = | 370.3 | nM | 6.43 |
| CHEMBL3360036 | — | IC50 | = | 457.7 | nM | 6.34 |
| CHEMBL3360040 | — | IC50 | = | 585.6 | nM | 6.23 |
| CHEMBL3360039 | — | IC50 | = | 607.1 | nM | 6.22 |
| CHEMBL3360037 | — | IC50 | = | 608.1 | nM | 6.22 |
| CHEMBL3360058 | — | IC50 | = | 18080.0 | nM | 4.74 |