Assay Detail
Functional
CHEMBL3371884
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of norcantharidin derivatives as protein phosphatase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.59 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 4.92 |
| CHEMBL3358348 | — | — | 1 | 4.74 |
| CHEMBL3358351 | — | — | 1 | 4.70 |
| CHEMBL3358347 | — | — | 1 | 4.62 |
| CHEMBL3358355 | — | — | 1 | 4.59 |
| CHEMBL3358349 | — | — | 1 | 4.55 |
| CHEMBL3358356 | — | — | 1 | 4.49 |
| CHEMBL3358350 | — | — | 1 | 4.46 |
| CHEMBL3358352 | — | — | 1 | 4.44 |
| CHEMBL3358354 | — | — | 1 | 4.41 |
| CHEMBL3358353 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3358348 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL3358351 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL3358347 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL3358355 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL3358349 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL3358356 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL3358350 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL3358352 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL3358354 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL3358353 | — | IC50 | > | 100000.0 | nM | - |