Assay Detail
Binding
CHEMBL3371890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of protein phosphatase-1 (unknown origin) using phosphopeptide (Lys-Arg-pThr-Ile-Arg) substrate incubated for 60 mins by colorimetric analysis based serine/threonine assay
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of norcantharidin derivatives as protein phosphatase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.97 | 6.70 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358348 | — | — | 2 | 6.70 |
| CHEMBL3358355 | — | — | 1 | 5.64 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358348 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3358355 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3358348 | — | Inhibition | - | % | - |