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Assay Detail

CHEMBL3371904

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Plasmodium falciparum NF54 by SYBR-green based assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
Ramachandran S, Hameed P S, Srivastava A, Shanbhag G, Morayya S, Rautela N, Awasthy D, Kavanagh S, Bharath S, Reddy J, Panduga V, Prabhakar KR, Saralaya R, Nanduri R, Raichurkar A, Menasinakai S, Achar V, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Waterson D, Lee MC, Coburn-Flynn O, Fidock DA, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK.
J Med Chem (2014) 57 : 6642 -6652
PubMed 25007124 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 7.34 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1450 ATOVAQUONE 4.0 1 8.85
CHEMBL269671 ARTEMISININ 3.0 1 8.15
CHEMBL3321981 1 7.89
CHEMBL76 CHLOROQUINE 4.0 1 7.77
CHEMBL3321980 1 7.77
CHEMBL36 PYRIMETHAMINE 4.0 1 7.55
CHEMBL3321967 1 7.54
CHEMBL3321972 1 7.44
CHEMBL3321970 1 7.41
CHEMBL3321978 1 7.36
CHEMBL3321977 1 7.32
CHEMBL3321871 1 7.28
CHEMBL3321973 1 7.28
CHEMBL3321974 1 7.25
CHEMBL3321979 1 7.10
CHEMBL3321965 1 7.09
CHEMBL3321975 1 7.03
CHEMBL3321963 1 7.03
CHEMBL3321968 1 6.96
CHEMBL3321964 1 6.89
CHEMBL3321873 1 6.89
CHEMBL3321870 1 6.68
CHEMBL3321976 1 6.35
CHEMBL3321971 1 -
CHEMBL3321969 1 -
CHEMBL3321966 1 -
CHEMBL3321872 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1450 ATOVAQUONE IC50 = 1.4 nM 8.85
CHEMBL269671 ARTEMISININ IC50 = 7.1 nM 8.15
CHEMBL3321981 IC50 = 13.0 nM 7.89
CHEMBL76 CHLOROQUINE IC50 = 17.1 nM 7.77
CHEMBL3321980 IC50 = 17.0 nM 7.77
CHEMBL36 PYRIMETHAMINE IC50 = 28.3 nM 7.55
CHEMBL3321967 IC50 = 29.0 nM 7.54
CHEMBL3321972 IC50 = 36.0 nM 7.44
CHEMBL3321970 IC50 = 39.0 nM 7.41
CHEMBL3321978 IC50 = 44.0 nM 7.36
CHEMBL3321977 IC50 = 48.0 nM 7.32
CHEMBL3321871 IC50 = 53.0 nM 7.28
CHEMBL3321973 IC50 = 53.0 nM 7.28
CHEMBL3321974 IC50 = 56.0 nM 7.25
CHEMBL3321979 IC50 = 80.0 nM 7.10
CHEMBL3321965 IC50 = 82.0 nM 7.09
CHEMBL3321975 IC50 = 94.0 nM 7.03
CHEMBL3321963 IC50 = 93.0 nM 7.03
CHEMBL3321968 IC50 = 110.0 nM 6.96
CHEMBL3321964 IC50 = 130.0 nM 6.89
CHEMBL3321873 IC50 = 130.0 nM 6.89
CHEMBL3321870 IC50 = 210.0 nM 6.68
CHEMBL3321976 IC50 = 450.0 nM 6.35
CHEMBL3321971 IC50 > 500.0 nM -
CHEMBL3321969 IC50 > 500.0 nM -
CHEMBL3321966 IC50 > 500.0 nM -
CHEMBL3321872 IC50 > 500.0 nM -