Assay Detail
Binding
CHEMBL3372049
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Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.15 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 6.37 |
| CHEMBL3311028 | — | — | 1 | - |
| CHEMBL3311027 | — | — | 1 | - |
| CHEMBL3311026 | — | — | 1 | - |
| CHEMBL3311025 | — | — | 1 | - |
| CHEMBL3311024 | — | — | 1 | - |
| CHEMBL3311023 | — | — | 1 | - |
| CHEMBL3310916 | — | — | 1 | - |
| CHEMBL3310915 | — | — | 1 | - |
| CHEMBL3310914 | — | — | 1 | - |
| CHEMBL3310913 | — | — | 1 | - |
| CHEMBL3310912 | — | — | 1 | - |
| CHEMBL3310911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL897 | PROBENECID | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL3311028 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3311027 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3311026 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3311025 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3311024 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3311023 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3310916 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3310915 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3310914 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3310913 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3310912 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3310911 | — | Ki | > | 10000.0 | nM | - |