Assay Detail
Binding
CHEMBL3372050
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Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.71 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL3310911 | — | — | 1 | 6.78 |
| CHEMBL3310915 | — | — | 1 | 6.77 |
| CHEMBL3311027 | — | — | 1 | 6.72 |
| CHEMBL3311024 | — | — | 1 | 6.70 |
| CHEMBL3311023 | — | — | 1 | 6.67 |
| CHEMBL3311028 | — | — | 1 | 6.65 |
| CHEMBL3310916 | — | — | 1 | 6.64 |
| CHEMBL3310912 | — | — | 1 | 6.63 |
| CHEMBL3311025 | — | — | 1 | 6.61 |
| CHEMBL3310914 | — | — | 1 | 6.60 |
| CHEMBL3311026 | — | — | 1 | 6.58 |
| CHEMBL3310913 | — | — | 1 | 6.58 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3310911 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL3310915 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL3311027 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL3311024 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL3311023 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL3311028 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL3310916 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL3310912 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL3311025 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL3310914 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL3311026 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL3310913 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL897 | PROBENECID | Ki | = | 360.0 | nM | 6.44 |