Assay Detail
Functional
CHEMBL3372149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.70 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3323016 | — | — | 1 | 9.48 |
| CHEMBL3323011 | — | — | 1 | 8.89 |
| CHEMBL3323117 | — | — | 1 | 7.72 |
| CHEMBL3322994 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3323016 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL3323011 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3323117 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3322994 | — | IC50 | = | 0.0038 | nM | - |