Assay Detail
Binding
CHEMBL3372398
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Inhibition of human ATR using ATP substrate measured after 3 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.24 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355476 | — | — | 1 | 10.00 |
| CHEMBL3355474 | — | — | 1 | 9.70 |
| CHEMBL3355475 | — | — | 1 | 9.40 |
| CHEMBL3355480 | — | — | 1 | 9.30 |
| CHEMBL3355473 | — | — | 1 | 9.00 |
| CHEMBL3355472 | — | — | 1 | 8.30 |
| CHEMBL3355478 | — | — | 1 | 8.22 |
| CHEMBL3352848 | — | — | 1 | 7.58 |
| CHEMBL3355477 | — | — | 1 | 7.47 |
| CHEMBL3355471 | — | — | 1 | 7.41 |
| CHEMBL3355470 | — | — | 1 | 7.02 |
| CHEMBL3355469 | — | — | 1 | 7.02 |
| CHEMBL3355479 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355476 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3355474 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3355475 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3355480 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3355473 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3355472 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3355478 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3352848 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3355477 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3355471 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3355470 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3355469 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3355479 | — | IC50 | = | 190.0 | nM | 6.72 |