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Assay Detail

CHEMBL3372545

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Functional
Cytotoxicity against human MCF7 cells after 96 hrs by Giemsa staining-based light microscopy
ChEMBL ↗
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.
J Med Chem (2014) 57 : 6531 -6552
PubMed 25025991 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 6.73 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL107 COLCHICINE 4.0 1 8.30
CHEMBL67 COMBRETASTATIN A4 -1.0 1 7.89
CHEMBL3318100 — — 1 7.82
CHEMBL3318101 — — 1 7.82
CHEMBL3318108 — — 1 7.80
CHEMBL3318105 — — 1 7.70
CHEMBL3318103 — — 1 7.70
CHEMBL3318112 — — 1 7.54
CHEMBL3318102 — — 1 7.52
CHEMBL3318107 — — 1 7.37
CHEMBL3318111 — — 1 7.30
CHEMBL3318106 — — 1 7.22
CHEMBL3318124 — — 1 7.00
CHEMBL3318095 — — 1 6.72
CHEMBL3318090 — — 1 6.70
CHEMBL3318092 — — 1 6.60
CHEMBL3318115 — — 1 6.60
CHEMBL3318119 — — 1 6.40
CHEMBL3318120 — — 1 6.35
CHEMBL3318122 — — 1 6.33
CHEMBL3318118 — — 1 6.28
CHEMBL3318114 — — 1 6.22
CHEMBL3318089 — — 1 6.22
CHEMBL3318085 — — 1 6.16
CHEMBL3318121 — — 1 6.08
CHEMBL3318091 — — 1 6.00
CHEMBL3318104 — — 1 6.00
CHEMBL3318094 — — 1 5.89
CHEMBL3318125 — — 1 5.77
CHEMBL3318113 — — 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL107 COLCHICINE IC50 = 5.0 nM 8.30
CHEMBL67 COMBRETASTATIN A4 IC50 = 13.0 nM 7.89
CHEMBL3318100 — IC50 = 15.0 nM 7.82
CHEMBL3318101 — IC50 = 15.0 nM 7.82
CHEMBL3318108 — IC50 = 16.0 nM 7.80
CHEMBL3318105 — IC50 = 20.0 nM 7.70
CHEMBL3318103 — IC50 = 20.0 nM 7.70
CHEMBL3318112 — IC50 = 29.0 nM 7.54
CHEMBL3318102 — IC50 = 30.0 nM 7.52
CHEMBL3318107 — IC50 = 43.0 nM 7.37
CHEMBL3318111 — IC50 = 50.0 nM 7.30
CHEMBL3318106 — IC50 = 60.0 nM 7.22
CHEMBL3318124 — IC50 = 100.0 nM 7.00
CHEMBL3318095 — IC50 = 190.0 nM 6.72
CHEMBL3318090 — IC50 = 200.0 nM 6.70
CHEMBL3318115 — IC50 = 250.0 nM 6.60
CHEMBL3318092 — IC50 = 250.0 nM 6.60
CHEMBL3318119 — IC50 = 400.0 nM 6.40
CHEMBL3318120 — IC50 = 450.0 nM 6.35
CHEMBL3318122 — IC50 = 470.0 nM 6.33
CHEMBL3318118 — IC50 = 530.0 nM 6.28
CHEMBL3318114 — IC50 = 600.0 nM 6.22
CHEMBL3318089 — IC50 = 600.0 nM 6.22
CHEMBL3318085 — IC50 = 700.0 nM 6.16
CHEMBL3318121 — IC50 = 830.0 nM 6.08
CHEMBL3318091 — IC50 = 1000.0 nM 6.00
CHEMBL3318104 — IC50 = 1000.0 nM 6.00
CHEMBL3318094 — IC50 = 1300.0 nM 5.89
CHEMBL3318125 — IC50 = 1700.0 nM 5.77
CHEMBL3318113 — IC50 = 3500.0 nM 5.46
CHEMBL3318123 — IC50 = 4500.0 nM 5.35
CHEMBL3318088 — IC50 = 4500.0 nM 5.35