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Assay Detail

CHEMBL3372741

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Functional
Antiparasitic activity against Toxoplasma gondii infected in human foreskin fibroblasts assessed as tachyzoite growth inhibition after 5 days by colorimetric assay
ChEMBL ↗
146
Total Activities
73
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Confidence 1 — Organism
Curated By Autocuration

Target

Toxoplasma gondii (CHEMBL612888) ↗
Type ORGANISM
Organism Toxoplasma gondii

Publication

Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii.
D'Ascenzio M, Bizzarri B, De Monte C, Carradori S, Bolasco A, Secci D, Rivanera D, Faulhaber N, Bordón C, Jones-Brando L.
Eur J Med Chem (2014) 86 : 17 -30
PubMed 25140751 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 73 4.50 6.05
IC90 73 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3335641 — — 2 6.05
CHEMBL3335726 — — 2 5.54
CHEMBL3335811 — — 2 5.41
CHEMBL3335813 — — 2 5.10
CHEMBL22 TRIMETHOPRIM 4.0 2 4.89
CHEMBL3335822 — — 2 4.82
CHEMBL3335821 — — 2 4.72
CHEMBL3335823 — — 2 4.70
CHEMBL3335807 — — 2 4.70
CHEMBL3335820 — — 2 4.64
CHEMBL3335818 — — 2 4.64
CHEMBL3335637 — — 2 4.64
CHEMBL3334524 — — 2 4.62
CHEMBL3335642 — — 2 4.62
CHEMBL591000 — — 2 4.57
CHEMBL591053 — — 2 4.55
CHEMBL3335640 — — 2 4.51
CHEMBL3335717 — — 2 4.44
CHEMBL3334534 — — 2 4.44
CHEMBL3335817 — — 2 4.44
CHEMBL3334528 — — 2 4.43
CHEMBL3334537 — — 2 4.42
CHEMBL3334518 — — 2 4.37
CHEMBL3334523 — — 2 4.37
CHEMBL3335816 — — 2 4.33
CHEMBL3335808 — — 2 4.28
CHEMBL3334515 — — 2 4.28
CHEMBL3334535 — — 2 4.28
CHEMBL3335727 — — 2 4.28
CHEMBL3335720 — — 2 4.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3335641 — IC50 = 900.0 nM 6.05
CHEMBL3335726 — IC50 = 2900.0 nM 5.54
CHEMBL3335811 — IC50 = 3900.0 nM 5.41
CHEMBL3335813 — IC50 = 8000.0 nM 5.10
CHEMBL22 TRIMETHOPRIM IC50 = 13000.0 nM 4.89
CHEMBL3335822 — IC50 = 15000.0 nM 4.82
CHEMBL3335821 — IC50 = 19000.0 nM 4.72
CHEMBL3335823 — IC50 = 20000.0 nM 4.70
CHEMBL3335807 — IC50 = 20000.0 nM 4.70
CHEMBL3335637 — IC50 = 23000.0 nM 4.64
CHEMBL3335820 — IC50 = 23000.0 nM 4.64
CHEMBL3335818 — IC50 = 23000.0 nM 4.64
CHEMBL3334524 — IC50 = 24000.0 nM 4.62
CHEMBL3335642 — IC50 = 24000.0 nM 4.62
CHEMBL591000 — IC50 = 27000.0 nM 4.57
CHEMBL591053 — IC50 = 28000.0 nM 4.55
CHEMBL3335640 — IC50 = 31000.0 nM 4.51
CHEMBL3334534 — IC50 = 36000.0 nM 4.44
CHEMBL3335717 — IC50 = 36000.0 nM 4.44
CHEMBL3335817 — IC50 = 36000.0 nM 4.44
CHEMBL3334528 — IC50 = 37000.0 nM 4.43
CHEMBL3334537 — IC50 = 38000.0 nM 4.42
CHEMBL3334523 — IC50 = 43000.0 nM 4.37
CHEMBL3334518 — IC50 = 43000.0 nM 4.37
CHEMBL3335816 — IC50 = 47000.0 nM 4.33
CHEMBL3334535 — IC50 = 52000.0 nM 4.28
CHEMBL3335808 — IC50 = 53000.0 nM 4.28
CHEMBL3334515 — IC50 = 53000.0 nM 4.28
CHEMBL3335727 — IC50 = 52000.0 nM 4.28
CHEMBL3335720 — IC50 = 55000.0 nM 4.26
CHEMBL3335812 — IC50 = 56000.0 nM 4.25
CHEMBL3334519 — IC50 = 58000.0 nM 4.24
CHEMBL3334529 — IC50 = 61000.0 nM 4.21
CHEMBL3335724 — IC50 = 64000.0 nM 4.19
CHEMBL3335728 — IC50 = 74000.0 nM 4.13
CHEMBL3334526 — IC50 = 76000.0 nM 4.12
CHEMBL592240 — IC50 = 79000.0 nM 4.10
CHEMBL3334532 — IC50 = 82000.0 nM 4.09
CHEMBL3334520 — IC50 = 88000.0 nM 4.06
CHEMBL3335639 — IC50 = 89000.0 nM 4.05
CHEMBL3335635 — IC50 = 97000.0 nM 4.01
CHEMBL3335815 — IC50 = 99000.0 nM 4.00
CHEMBL3335726 — IC90 = 7000.0 nM -
CHEMBL3335821 — IC90 = 120000.0 nM -
CHEMBL3335808 — IC90 = 401000.0 nM -
CHEMBL3335822 — IC90 = 121000.0 nM -
CHEMBL3335807 — IC90 = 129000.0 nM -
CHEMBL3335728 — IC90 = 406000.0 nM -
CHEMBL3335727 — IC90 = 268000.0 nM -
CHEMBL3335823 — IC90 = 88000.0 nM -