Assay Detail
Functional
CHEMBL3372887
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Antiproliferative activity against human HeLa cells assessed as growth inhibition after 24 to 72 hrs
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Vanillin-derived antiproliferative compounds influence Plk1 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 48 | 5.03 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344200 | — | — | 1 | 6.66 |
| CHEMBL3344201 | — | — | 1 | 6.40 |
| CHEMBL3344146 | — | — | 1 | 6.40 |
| CHEMBL3344194 | — | — | 1 | 6.36 |
| CHEMBL3344186 | — | — | 1 | 6.36 |
| CHEMBL3344193 | — | — | 1 | 6.05 |
| CHEMBL3344190 | — | — | 1 | 5.62 |
| CHEMBL3344196 | — | — | 1 | 5.60 |
| CHEMBL3344140 | — | — | 1 | 5.57 |
| CHEMBL3344199 | — | — | 1 | 5.48 |
| CHEMBL3344197 | — | — | 1 | 5.41 |
| CHEMBL3344198 | — | — | 1 | 5.40 |
| CHEMBL3344195 | — | — | 1 | 5.40 |
| CHEMBL3344188 | — | — | 1 | 5.32 |
| CHEMBL3344130 | — | — | 1 | 5.30 |
| CHEMBL3344192 | — | — | 1 | 5.30 |
| CHEMBL3344191 | — | — | 1 | 5.30 |
| CHEMBL3344145 | — | — | 1 | 5.30 |
| CHEMBL3344189 | — | — | 1 | 5.29 |
| CHEMBL1623894 | — | — | 1 | 5.21 |
| CHEMBL3344187 | — | — | 1 | 5.19 |
| CHEMBL3217822 | — | — | 1 | 5.10 |
| CHEMBL3344137 | — | — | 1 | 4.92 |
| CHEMBL1619503 | — | — | 1 | 4.89 |
| CHEMBL1621767 | — | — | 1 | 4.80 |
| CHEMBL3344148 | — | — | 1 | 4.75 |
| CHEMBL1616543 | — | — | 1 | 4.75 |
| CHEMBL1619380 | — | — | 1 | 4.75 |
| CHEMBL1625188 | — | — | 1 | 4.75 |
| CHEMBL1616819 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344200 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3344201 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3344146 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3344194 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3344186 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3344193 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3344190 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3344196 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3344140 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3344199 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3344197 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3344198 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3344195 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3344188 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3344145 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3344130 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3344191 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3344192 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3344189 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1623894 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3344187 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3217822 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3344137 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1619503 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1621767 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1616543 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1619380 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1625188 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3344148 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1616819 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3341782 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3344147 | — | EC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3344139 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1618570 | — | EC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL3344134 | — | EC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL3344143 | — | EC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL3344142 | — | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL3344184 | — | EC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL3344141 | — | EC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL1619289 | — | EC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL3344135 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3344144 | — | EC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL3344131 | — | EC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL3344138 | — | EC50 | - | — | - | |
| CHEMBL3344136 | — | EC50 | - | — | - | |
| CHEMBL3344185 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3344133 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3344132 | — | EC50 | - | — | - |