Assay Detail
Functional
CHEMBL3372985
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Cytotoxicity against human NCI-H1299 cells assessed as cell viability after 72 hrs by CellTiterGlo assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.88 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355534 | — | — | 1 | 6.72 |
| CHEMBL3355537 | — | — | 1 | 6.68 |
| CHEMBL3355536 | — | — | 1 | 6.66 |
| CHEMBL3355538 | — | — | 1 | 6.64 |
| CHEMBL3355539 | — | — | 1 | 6.51 |
| CHEMBL3355535 | — | — | 1 | 6.35 |
| CHEMBL3355533 | — | — | 1 | 6.26 |
| CHEMBL3355531 | — | — | 1 | 6.16 |
| CHEMBL3355528 | — | — | 1 | 6.11 |
| CHEMBL3355518 | — | — | 1 | 6.00 |
| CHEMBL3355532 | — | — | 1 | 5.70 |
| CHEMBL3355524 | — | — | 1 | 5.48 |
| CHEMBL3355519 | — | — | 1 | 5.23 |
| CHEMBL3355525 | — | — | 1 | 5.19 |
| CHEMBL3355527 | — | — | 1 | 5.14 |
| CHEMBL3355530 | — | — | 1 | 5.03 |
| CHEMBL3355523 | — | — | 1 | 5.02 |
| CHEMBL3355522 | — | — | 1 | 5.01 |
| CHEMBL3355529 | — | — | 1 | - |
| CHEMBL3355521 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355534 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3355537 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3355536 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3355538 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3355539 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3355535 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3355533 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3355531 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3355528 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3355518 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3355532 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3355524 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3355519 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3355525 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3355527 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3355530 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3355523 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3355522 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3355529 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3355521 | — | EC50 | > | 10000.0 | nM | - |