Assay Detail
Functional
CHEMBL3373000
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Cytotoxicity against human HT-29 cells after 72 hrs under normoxia conditions by SRB assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 6-(nitroimidazole-1H-alkyloxyl)-4-anilinoquinazolines as efficient EGFR inhibitors exerting cytotoxic effects both under normoxia and hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.19 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355884 | — | — | 1 | 5.73 |
| CHEMBL3355875 | — | — | 1 | 5.66 |
| CHEMBL3355882 | — | — | 1 | 5.53 |
| CHEMBL3355885 | — | — | 1 | 5.51 |
| CHEMBL3355881 | — | — | 1 | 5.45 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.44 |
| CHEMBL3355878 | — | — | 1 | 5.35 |
| CHEMBL3355879 | — | — | 1 | 5.26 |
| CHEMBL3355889 | — | — | 1 | 5.09 |
| CHEMBL3355874 | — | — | 1 | 5.08 |
| CHEMBL3355880 | — | — | 1 | 5.00 |
| CHEMBL3355877 | — | — | 1 | 4.89 |
| CHEMBL3355883 | — | — | 1 | 4.81 |
| CHEMBL3355890 | — | — | 1 | 4.80 |
| CHEMBL3355876 | — | — | 1 | 4.75 |
| CHEMBL3355888 | — | — | 1 | 4.63 |
| CHEMBL3355886 | — | — | 1 | - |
| CHEMBL3355887 | — | — | 1 | - |
| CHEMBL3355873 | — | — | 1 | - |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355884 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL3355875 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL3355882 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL3355885 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL3355881 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL3355878 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL3355879 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL3355889 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL3355874 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL3355880 | — | IC50 | = | 10080.0 | nM | 5.00 |
| CHEMBL3355877 | — | IC50 | = | 12890.0 | nM | 4.89 |
| CHEMBL3355883 | — | IC50 | = | 15480.0 | nM | 4.81 |
| CHEMBL3355890 | — | IC50 | = | 15720.0 | nM | 4.80 |
| CHEMBL3355876 | — | IC50 | = | 17580.0 | nM | 4.75 |
| CHEMBL3355888 | — | IC50 | = | 23240.0 | nM | 4.63 |
| CHEMBL3355886 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3355887 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3355873 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | > | 50000.0 | nM | - |