Assay Detail
Functional
CHEMBL3373063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.48 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356854 | — | — | 1 | 7.85 |
| CHEMBL3040381 | — | — | 1 | 7.75 |
| CHEMBL3356853 | — | — | 1 | 6.84 |
| CHEMBL407196 | NEUROTENSIN | — | 1 | - |
| CHEMBL3356855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356854 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3040381 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3356853 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL407196 | NEUROTENSIN | EC50 | > | 100.0 | nM | - |
| CHEMBL3356855 | — | EC50 | > | 10.0 | nM | - |