Assay Detail
Binding
CHEMBL3373067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.05 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3040381 | — | — | 1 | 8.15 |
| CHEMBL407196 | NEUROTENSIN | — | 1 | 7.68 |
| CHEMBL3356854 | — | — | 1 | 7.06 |
| CHEMBL3356855 | — | — | 1 | 6.32 |
| CHEMBL3356853 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3040381 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL407196 | NEUROTENSIN | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3356854 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL3356855 | — | Ki | = | 474.0 | nM | 6.32 |
| CHEMBL3356853 | — | Ki | = | 959.0 | nM | 6.02 |