Assay Detail
Functional
CHEMBL3373087
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Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.55 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318100 | — | — | 1 | 8.00 |
| CHEMBL3318115 | — | — | 1 | 7.10 |
| CHEMBL3318085 | — | — | 1 | 6.70 |
| CHEMBL3318113 | — | — | 1 | 6.00 |
| CHEMBL3318125 | — | — | 1 | 6.00 |
| CHEMBL3318114 | — | — | 1 | 5.52 |
| CHEMBL3318123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318100 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3318115 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3318085 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3318113 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3318125 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3318114 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3318123 | — | IC50 | > | 10000.0 | nM | - |