Assay Detail
Functional
CHEMBL3373091
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Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318100 | — | — | 1 | 9.00 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.89 |
| CHEMBL3318115 | — | — | 1 | 7.77 |
| CHEMBL3318085 | — | — | 1 | 7.70 |
| CHEMBL3318114 | — | — | 1 | 7.05 |
| CHEMBL3318113 | — | — | 1 | 6.70 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.70 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.38 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.48 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318100 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3318115 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3318085 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3318114 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3318113 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL107 | COLCHICINE | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5000.0 | nM | 5.30 |