Assay Detail
Binding
CHEMBL3373147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]HT from human 5-HT7 receptor expressed in CHO cells by liquid scintillation counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT₂B and 5-HT₇ receptor antagonists. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.65 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310714 | — | — | 1 | 8.64 |
| CHEMBL3310713 | — | — | 1 | 8.40 |
| CHEMBL3310113 | — | — | 1 | 8.39 |
| CHEMBL3310122 | — | — | 1 | 8.39 |
| CHEMBL3310123 | — | — | 1 | 8.37 |
| CHEMBL3310111 | — | — | 1 | 7.85 |
| CHEMBL3139188 | — | — | 1 | 7.75 |
| CHEMBL3310112 | — | — | 1 | 7.54 |
| CHEMBL3310115 | — | — | 1 | 7.48 |
| CHEMBL3310117 | — | — | 1 | 7.39 |
| CHEMBL3310109 | — | — | 1 | 7.39 |
| CHEMBL3310120 | — | — | 1 | 7.37 |
| CHEMBL3310118 | — | — | 1 | 7.30 |
| CHEMBL3310121 | — | — | 1 | 7.24 |
| CHEMBL3310116 | — | — | 1 | 7.06 |
| CHEMBL3310114 | — | — | 1 | 6.80 |
| CHEMBL3310119 | — | — | 1 | 6.75 |
| CHEMBL3310110 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310714 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3310713 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3310113 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL3310122 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL3310123 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL3310111 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3139188 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3310112 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3310115 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3310117 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3310109 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3310120 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3310118 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3310121 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL3310116 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL3310114 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3310119 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3310110 | — | Ki | > | 1000.0 | nM | - |