Assay Detail
Binding
CHEMBL3373418
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Displacement of [3H]epibatidine from Torpedo californica muscle-type nAChR after 90 mins by liquid scintillation counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.52 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337857 | — | — | 1 | 7.85 |
| CHEMBL3337867 | — | — | 1 | 7.12 |
| CHEMBL3355098 | — | — | 1 | 7.09 |
| CHEMBL3337866 | — | — | 1 | 6.82 |
| CHEMBL3305985 | ALCURONIUM | 2.0 | 1 | 6.63 |
| CHEMBL3337863 | — | — | 1 | 6.60 |
| CHEMBL3355097 | — | — | 1 | 6.54 |
| CHEMBL3337861 | — | — | 1 | 6.41 |
| CHEMBL3337862 | — | — | 1 | 6.34 |
| CHEMBL3337865 | — | — | 1 | 6.17 |
| CHEMBL3337860 | — | — | 1 | 6.09 |
| CHEMBL3337859 | — | — | 1 | 5.82 |
| CHEMBL3337858 | — | — | 1 | 5.28 |
| CHEMBL380352 | CARACURINE V | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337857 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3337867 | — | Ki | = | 75.1 | nM | 7.12 |
| CHEMBL3355098 | — | Ki | = | 81.9 | nM | 7.09 |
| CHEMBL3337866 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3305985 | ALCURONIUM | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL3337863 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3355097 | — | Ki | = | 290.5 | nM | 6.54 |
| CHEMBL3337861 | — | Ki | = | 390.1 | nM | 6.41 |
| CHEMBL3337862 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL3337865 | — | Ki | = | 668.8 | nM | 6.17 |
| CHEMBL3337860 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL3337859 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3337858 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL380352 | CARACURINE V | Ki | > | 100000.0 | nM | - |