Assay Detail
Binding
CHEMBL3373419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
22
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.11 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3305985 | ALCURONIUM | 2.0 | 1 | 8.70 |
| CHEMBL3337858 | — | — | 1 | 8.10 |
| CHEMBL3337859 | — | — | 1 | 7.96 |
| CHEMBL3337863 | — | — | 2 | 7.92 |
| CHEMBL3355097 | — | — | 2 | 7.50 |
| CHEMBL3337867 | — | — | 2 | 7.44 |
| CHEMBL3355098 | — | — | 2 | 7.31 |
| CHEMBL3337857 | — | — | 1 | 7.02 |
| CHEMBL3337866 | — | — | 2 | 6.58 |
| CHEMBL3337862 | — | — | 2 | 6.50 |
| CHEMBL3337860 | — | — | 1 | 6.47 |
| CHEMBL3337861 | — | — | 2 | 6.39 |
| CHEMBL380352 | CARACURINE V | — | 1 | 6.36 |
| CHEMBL3337865 | — | — | 2 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3305985 | ALCURONIUM | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3337858 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3337859 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3337863 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3337863 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3355097 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3355097 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3337867 | — | EC50 | = | 36.31 | nM | 7.44 |
| CHEMBL3337867 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3355098 | — | EC50 | = | 48.98 | nM | 7.31 |
| CHEMBL3355098 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3337857 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3337866 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3337866 | — | EC50 | = | 263.03 | nM | 6.58 |
| CHEMBL3337862 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3337862 | — | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL3337860 | — | EC50 | = | 339.0 | nM | 6.47 |
| CHEMBL3337861 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3337861 | — | EC50 | = | 407.38 | nM | 6.39 |
| CHEMBL380352 | CARACURINE V | EC50 | = | 436.0 | nM | 6.36 |
| CHEMBL3337865 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3337865 | — | EC50 | = | 501.19 | nM | 6.30 |