Assay Detail
Binding
CHEMBL3373764
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Inhibition of CA-9 (unknown origin) after 15 mins by CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.03 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3310984 | — | — | 1 | 7.16 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.14 |
| CHEMBL3310985 | — | — | 1 | 7.13 |
| CHEMBL1332361 | — | — | 1 | 7.12 |
| CHEMBL1533910 | — | — | 1 | 7.10 |
| CHEMBL1382128 | — | — | 1 | 7.05 |
| CHEMBL182659 | — | — | 1 | 7.05 |
| CHEMBL1372946 | — | — | 1 | 7.03 |
| CHEMBL1621411 | — | — | 1 | 7.03 |
| CHEMBL362436 | — | — | 1 | 6.89 |
| CHEMBL287486 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3310984 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3310985 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1332361 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1533910 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1382128 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL182659 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1372946 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1621411 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL362436 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL287486 | — | IC50 | = | 217.0 | nM | 6.66 |