Assay Detail
Binding
CHEMBL3374135
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Inhibition of PDE7A (unknown origin)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.72 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360172 | — | — | 1 | 9.49 |
| CHEMBL3360170 | — | — | 1 | 9.17 |
| CHEMBL3360169 | — | — | 1 | 8.96 |
| CHEMBL3360171 | — | — | 1 | 8.92 |
| CHEMBL3354179 | — | — | 1 | 8.70 |
| CHEMBL3360167 | — | — | 1 | 8.68 |
| CHEMBL3360168 | — | — | 1 | 8.41 |
| CHEMBL3360166 | — | — | 1 | 8.06 |
| CHEMBL3360165 | — | — | 1 | 7.60 |
| CHEMBL3360161 | — | — | 1 | 7.39 |
| CHEMBL3360164 | — | — | 1 | 7.22 |
| CHEMBL3360160 | — | — | 1 | 7.21 |
| CHEMBL3360155 | — | — | 1 | 7.06 |
| CHEMBL3354160 | — | — | 1 | 6.82 |
| CHEMBL3354155 | — | — | 1 | 6.80 |
| CHEMBL3360154 | — | — | 1 | 6.54 |
| CHEMBL3360163 | — | — | 1 | 6.20 |
| CHEMBL3360159 | — | — | 1 | 5.64 |
| CHEMBL3360162 | — | — | 1 | - |
| CHEMBL3360158 | — | — | 1 | - |
| CHEMBL3360157 | — | — | 1 | - |
| CHEMBL3360156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360172 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL3360170 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL3360169 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3360171 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3354179 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3360167 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3360168 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3360166 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3360165 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3360161 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3360164 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3360160 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3360155 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3354160 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3354155 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3360154 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3360163 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3360159 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3360162 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3360158 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3360157 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3360156 | — | IC50 | > | 1000.0 | nM | - |