Assay Detail
Functional
CHEMBL3374138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL2 production from mouse activated lymphocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.47 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360171 | — | — | 1 | 6.89 |
| CHEMBL3360170 | — | — | 1 | 6.80 |
| CHEMBL3360167 | — | — | 1 | 6.58 |
| CHEMBL3360168 | — | — | 1 | 6.32 |
| CHEMBL3360166 | — | — | 1 | 5.77 |
| CHEMBL3360165 | — | — | 1 | - |
| CHEMBL3360169 | — | — | 1 | - |
| CHEMBL3360172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360171 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3360170 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3360167 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3360168 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3360166 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3360165 | — | IC50 | - | — | - | |
| CHEMBL3360169 | — | IC50 | - | — | - | |
| CHEMBL3360172 | — | IC50 | < | 100.0 | nM | - |