Assay Detail
Binding
CHEMBL3374139
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE3A (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (CHEMBL241) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360172 | — | — | 1 | 7.77 |
| CHEMBL3360170 | — | — | 1 | 7.54 |
| CHEMBL3360171 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360172 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3360170 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3360171 | — | IC50 | = | 37.0 | nM | 7.43 |