Assay Detail
Binding
CHEMBL3374140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5A (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.91 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360170 | — | — | 1 | 6.28 |
| CHEMBL3360172 | — | — | 1 | 5.54 |
| CHEMBL3360171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360170 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3360172 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3360171 | — | IC50 | > | 10000.0 | nM | - |