Assay Detail
ADMET
CHEMBL3374482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse J774 cells assessed as cell viability after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.84 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319020 | — | — | 1 | 4.90 |
| CHEMBL3319019 | — | — | 1 | 4.90 |
| CHEMBL256155 | — | — | 1 | 4.90 |
| CHEMBL3319017 | — | — | 1 | 4.66 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | - |
| CHEMBL3319021 | — | — | 1 | - |
| CHEMBL3319018 | — | — | 1 | - |
| CHEMBL3319016 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319020 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3319019 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL256155 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3319017 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 316000.0 | nM | - |
| CHEMBL3319021 | — | IC50 | - | — | - | |
| CHEMBL3319018 | — | IC50 | - | — | - | |
| CHEMBL3319016 | — | IC50 | - | — | - |