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Assay Detail

CHEMBL3374650

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Functional
Antimigratory activity against human SNB75 cells on matrix containing laminin after 24 hrs by 2-D migration assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SNB-75
Confidence 1 — Organism
Curated By Autocuration

Target

SNB-75 (CHEMBL614451)
Type CELL-LINE
Organism Homo sapiens

Publication

C-glycoside mimetics inhibit glioma stem cell proliferation, migration, and invasion.
Clarion L, Jacquard C, Sainte-Catherine O, Decoux M, Loiseau S, Rolland M, Lecouvey M, Hugnot JP, Volle JN, Virieux D, Pirat JL, Bakalara N.
J Med Chem (2014) 57 : 8293 -8306
PubMed 25211466 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.40 7.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3343410 1 7.57
CHEMBL3341777 1 7.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3343410 Ki = 27.0 nM 7.57
CHEMBL3341777 Ki = 60.0 nM 7.22