Assay Detail
Binding
CHEMBL3374782
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Inhibition of Yersinia pestis YopH using p-nitrophenol as substrate by spectrophotometry
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Yersinia pestis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.51 | 4.96 |
| Ki | 1 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 8.30 |
| CHEMBL3360592 | — | — | 1 | 4.96 |
| CHEMBL3360593 | — | — | 1 | 4.64 |
| CHEMBL3360594 | — | — | 1 | 4.40 |
| CHEMBL3360595 | — | — | 1 | 4.36 |
| CHEMBL3360596 | — | — | 1 | 4.20 |
| CHEMBL3360597 | — | — | 1 | - |
| CHEMBL3360598 | — | — | 1 | - |
| CHEMBL3360599 | — | — | 1 | - |
| CHEMBL3360600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3360592 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL3360593 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3360594 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL3360595 | — | IC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL3360596 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL3360597 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3360598 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3360599 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3360600 | — | IC50 | > | 200000.0 | nM | - |