Assay Detail
Binding
CHEMBL3374866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Probable C-C chemokine receptor type 3 (CHEMBL3406) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 6.84 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355932 | — | — | 1 | 8.00 |
| CHEMBL3355939 | — | — | 1 | 7.75 |
| CHEMBL3355944 | — | — | 1 | 7.62 |
| CHEMBL3355938 | — | — | 1 | 7.43 |
| CHEMBL3355945 | — | — | 1 | 7.32 |
| CHEMBL3355940 | — | — | 1 | 7.28 |
| CHEMBL3355934 | — | — | 1 | 7.21 |
| CHEMBL3355933 | — | — | 1 | 7.19 |
| CHEMBL3355964 | — | — | 1 | 7.19 |
| CHEMBL3355954 | — | — | 1 | 7.14 |
| CHEMBL3355952 | — | — | 1 | 7.13 |
| CHEMBL3355962 | — | — | 1 | 7.10 |
| CHEMBL3355950 | — | — | 1 | 7.07 |
| CHEMBL3355943 | — | — | 1 | 7.04 |
| CHEMBL3355963 | — | — | 1 | 6.96 |
| CHEMBL3355960 | — | — | 1 | 6.96 |
| CHEMBL3355953 | — | — | 1 | 6.92 |
| CHEMBL3355936 | — | — | 1 | 6.89 |
| CHEMBL3355935 | — | — | 1 | 6.68 |
| CHEMBL3355957 | — | — | 1 | 6.64 |
| CHEMBL3355965 | — | — | 1 | 6.57 |
| CHEMBL3355946 | — | — | 1 | 6.43 |
| CHEMBL3355948 | — | — | 1 | 6.42 |
| CHEMBL3355942 | — | — | 1 | 6.40 |
| CHEMBL3355961 | — | — | 1 | 6.39 |
| CHEMBL3355956 | — | — | 1 | 6.20 |
| CHEMBL3355951 | — | — | 1 | 6.19 |
| CHEMBL3355966 | — | — | 1 | 6.18 |
| CHEMBL3355959 | — | — | 1 | 6.13 |
| CHEMBL3355937 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355932 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3355939 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3355944 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3355938 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3355945 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL3355940 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL3355934 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3355933 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL3355964 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL3355954 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL3355952 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL3355962 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL3355950 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL3355943 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL3355960 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3355963 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3355953 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3355936 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3355935 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3355957 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL3355965 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL3355946 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL3355948 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL3355942 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3355961 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL3355956 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3355951 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL3355966 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL3355959 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL3355937 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3355958 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3355955 | — | Ki | - | — | - | |
| CHEMBL3355949 | — | Ki | - | — | - | |
| CHEMBL3355947 | — | Ki | - | — | - | |
| CHEMBL3355941 | — | Ki | - | — | - |