Assay Detail
Binding
CHEMBL3374867
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Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 5.92 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355941 | — | — | 1 | 7.00 |
| CHEMBL3355951 | — | — | 1 | 6.58 |
| CHEMBL3355932 | — | — | 1 | 6.58 |
| CHEMBL3355938 | — | — | 1 | 6.58 |
| CHEMBL3355964 | — | — | 1 | 6.50 |
| CHEMBL3355962 | — | — | 1 | 6.41 |
| CHEMBL3355945 | — | — | 1 | 6.38 |
| CHEMBL3355946 | — | — | 1 | 6.25 |
| CHEMBL3355952 | — | — | 1 | 6.25 |
| CHEMBL3355934 | — | — | 1 | 6.20 |
| CHEMBL3355939 | — | — | 1 | 6.14 |
| CHEMBL3355933 | — | — | 1 | 6.06 |
| CHEMBL3355936 | — | — | 1 | 6.02 |
| CHEMBL3355963 | — | — | 1 | 6.00 |
| CHEMBL3355956 | — | — | 1 | 5.96 |
| CHEMBL3355944 | — | — | 1 | 5.96 |
| CHEMBL3355954 | — | — | 1 | 5.89 |
| CHEMBL3355940 | — | — | 1 | 5.85 |
| CHEMBL3355949 | — | — | 1 | 5.77 |
| CHEMBL3355960 | — | — | 1 | 5.77 |
| CHEMBL3355935 | — | — | 1 | 5.64 |
| CHEMBL3355955 | — | — | 1 | 5.58 |
| CHEMBL3355966 | — | — | 1 | 5.48 |
| CHEMBL3355965 | — | — | 1 | 5.46 |
| CHEMBL3355947 | — | — | 1 | 5.43 |
| CHEMBL3355937 | — | — | 1 | 5.40 |
| CHEMBL3355943 | — | — | 1 | 5.34 |
| CHEMBL3355958 | — | — | 1 | 5.33 |
| CHEMBL3355959 | — | — | 1 | 5.28 |
| CHEMBL3355953 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355941 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3355951 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3355938 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3355932 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3355964 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL3355962 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3355945 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3355946 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3355952 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3355934 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3355939 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL3355933 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL3355936 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL3355963 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL3355944 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3355956 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3355954 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3355940 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3355960 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL3355949 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL3355935 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3355955 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3355966 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL3355965 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL3355947 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL3355937 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3355943 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL3355958 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL3355959 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL3355953 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL3355961 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL3355950 | — | Ki | - | — | - | |
| CHEMBL3355948 | — | Ki | - | — | - | |
| CHEMBL3355957 | — | Ki | - | — | - | |
| CHEMBL3355942 | — | Ki | - | — | - |