Assay Detail
Functional
CHEMBL3375116
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of lantadene analogs with marked in vitro inhibition of lung adenocarcinoma and TNF-α induced nuclear factor-kappa B (NF-κB) activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.81 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2413416 | Reduced Lantadene B | — | 1 | 6.37 |
| CHEMBL2413417 | Reduced Lantadene A | — | 1 | 6.10 |
| CHEMBL3318173 | — | — | 1 | 6.01 |
| CHEMBL3318175 | — | — | 1 | 5.95 |
| CHEMBL2413418 | — | — | 1 | 5.92 |
| CHEMBL3318174 | — | — | 1 | 5.88 |
| CHEMBL3318172 | — | — | 1 | 5.74 |
| CHEMBL3318169 | — | — | 1 | 5.71 |
| CHEMBL3318168 | — | — | 1 | 5.69 |
| CHEMBL3318179 | — | — | 1 | 5.59 |
| CHEMBL510691 | LANTADENE A | — | 1 | 5.55 |
| CHEMBL3318171 | — | — | 1 | 5.16 |
| CHEMBL3318170 | — | — | 1 | - |
| CHEMBL3318176 | — | — | 1 | - |
| CHEMBL461093 | — | — | 1 | - |
| CHEMBL3318177 | — | — | 1 | - |
| CHEMBL3318178 | — | — | 1 | - |
| CHEMBL447339 | — | — | 1 | - |
| CHEMBL507802 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2413416 | Reduced Lantadene B | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2413417 | Reduced Lantadene A | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3318173 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3318175 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2413418 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3318174 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3318172 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL3318169 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3318168 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL3318179 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL510691 | LANTADENE A | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL3318171 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL3318170 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3318176 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL461093 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3318177 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3318178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL447339 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL507802 | — | IC50 | > | 10000.0 | nM | - |