Assay Detail
Functional
CHEMBL3375286
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Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel biaryl type α-noscapine congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.82 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3361006 | — | — | 1 | 5.05 |
| CHEMBL3360489 | — | — | 1 | 5.05 |
| CHEMBL3360491 | — | — | 1 | 5.04 |
| CHEMBL3360492 | — | — | 1 | 4.69 |
| CHEMBL3360490 | — | — | 1 | 4.67 |
| CHEMBL3361007 | — | — | 1 | 4.64 |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | 4.62 |
| CHEMBL3323242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3361006 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3360489 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3360491 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3360492 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL3360490 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL3361007 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL364713 | NOSCAPINE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3323242 | — | IC50 | - | — | - |