Assay Detail
Functional
CHEMBL3375287
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Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel biaryl type α-noscapine congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.36 | 4.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3361006 | — | — | 1 | 4.50 |
| CHEMBL3360491 | — | — | 1 | 4.49 |
| CHEMBL3360489 | — | — | 1 | 4.47 |
| CHEMBL3360492 | — | — | 1 | 4.37 |
| CHEMBL3360490 | — | — | 1 | 4.28 |
| CHEMBL3361007 | — | — | 1 | 4.24 |
| CHEMBL364713 | NOSCAPINE | 2.0 | 1 | 4.20 |
| CHEMBL3323242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3361006 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL3360491 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL3360489 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL3360492 | — | IC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL3360490 | — | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL3361007 | — | IC50 | = | 57300.0 | nM | 4.24 |
| CHEMBL364713 | NOSCAPINE | IC50 | = | 62900.0 | nM | 4.20 |
| CHEMBL3323242 | — | IC50 | - | — | - |