Assay Detail
Functional
CHEMBL3375330
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Growth inhibition of p53 null, pRb+ human NCI-H1299 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.07 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213805 | — | — | 1 | 5.60 |
| CHEMBL209467 | — | — | 1 | 4.94 |
| CHEMBL213302 | — | — | 1 | 4.68 |
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213805 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL209467 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL213302 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | IC50 | - | — | - |