Assay Detail
Functional
CHEMBL3375347
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Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation under hypoxia conditions after 72 hrs by SRB assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel 4-anilinoquinazoline derivatives as potent EGFR inhibitors both under normoxia and hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.38 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360609 | — | — | 1 | 6.75 |
| CHEMBL3360608 | — | — | 1 | 5.97 |
| CHEMBL3360607 | — | — | 1 | 5.93 |
| CHEMBL3360603 | — | — | 1 | 5.85 |
| CHEMBL3360612 | — | — | 1 | 5.82 |
| CHEMBL3360604 | — | — | 1 | 5.76 |
| CHEMBL3360618 | — | — | 1 | 5.71 |
| CHEMBL3360610 | — | — | 1 | 5.57 |
| CHEMBL3360602 | — | — | 1 | 5.37 |
| CHEMBL3360616 | — | — | 1 | 5.21 |
| CHEMBL3360605 | — | — | 1 | 5.19 |
| CHEMBL3360611 | — | — | 1 | 5.19 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.16 |
| CHEMBL3360606 | — | — | 1 | 5.12 |
| CHEMBL3360617 | — | — | 1 | 5.11 |
| CHEMBL3360619 | — | — | 1 | 5.08 |
| CHEMBL3360613 | — | — | 1 | 5.06 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.04 |
| CHEMBL3360620 | — | — | 1 | 5.00 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.93 |
| CHEMBL3360614 | — | — | 1 | 4.84 |
| CHEMBL3352899 | — | — | 1 | 4.70 |
| CHEMBL3360615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360609 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3360608 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3360607 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL3360603 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3360612 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3360604 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL3360618 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3360610 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3360602 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL3360616 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL3360605 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL3360611 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3360606 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL3360617 | — | IC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL3360619 | — | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL3360613 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3360620 | — | IC50 | = | 10120.0 | nM | 5.00 |
| CHEMBL939 | GEFITINIB | IC50 | = | 11670.0 | nM | 4.93 |
| CHEMBL3360614 | — | IC50 | = | 14380.0 | nM | 4.84 |
| CHEMBL3352899 | — | IC50 | = | 20180.0 | nM | 4.70 |
| CHEMBL3360615 | — | IC50 | > | 50000.0 | nM | - |