Assay Detail
Functional
CHEMBL3375348
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Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation under normoxia conditions after 72 hrs by SRB assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel 4-anilinoquinazoline derivatives as potent EGFR inhibitors both under normoxia and hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.30 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360609 | — | — | 1 | 5.88 |
| CHEMBL3360603 | — | — | 1 | 5.81 |
| CHEMBL3360608 | — | — | 1 | 5.60 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.53 |
| CHEMBL3360607 | — | — | 1 | 5.50 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.44 |
| CHEMBL3360612 | — | — | 1 | 5.42 |
| CHEMBL3360618 | — | — | 1 | 5.40 |
| CHEMBL3360604 | — | — | 1 | 5.39 |
| CHEMBL3360613 | — | — | 1 | 5.35 |
| CHEMBL3360610 | — | — | 1 | 5.35 |
| CHEMBL3360619 | — | — | 1 | 5.30 |
| CHEMBL3360605 | — | — | 1 | 5.25 |
| CHEMBL3360602 | — | — | 1 | 5.21 |
| CHEMBL3360616 | — | — | 1 | 5.12 |
| CHEMBL3360611 | — | — | 1 | 5.06 |
| CHEMBL3360606 | — | — | 1 | 5.01 |
| CHEMBL3352899 | — | — | 1 | 4.98 |
| CHEMBL3360617 | — | — | 1 | 4.96 |
| CHEMBL3360620 | — | — | 1 | 4.96 |
| CHEMBL3360614 | — | — | 1 | 4.85 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | - |
| CHEMBL3360615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360609 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL3360603 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3360608 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL3360607 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL3360612 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL3360618 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL3360604 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL3360613 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL3360610 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3360619 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL3360605 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL3360602 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL3360616 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL3360611 | — | IC50 | = | 8770.0 | nM | 5.06 |
| CHEMBL3360606 | — | IC50 | = | 9860.0 | nM | 5.01 |
| CHEMBL3352899 | — | IC50 | = | 10510.0 | nM | 4.98 |
| CHEMBL3360617 | — | IC50 | = | 10880.0 | nM | 4.96 |
| CHEMBL3360620 | — | IC50 | = | 10840.0 | nM | 4.96 |
| CHEMBL3360614 | — | IC50 | = | 14090.0 | nM | 4.85 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL3360615 | — | IC50 | > | 50000.0 | nM | - |