Assay Detail
Functional
CHEMBL3375349
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Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation under hypoxia conditions after 72 hrs by SRB assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel 4-anilinoquinazoline derivatives as potent EGFR inhibitors both under normoxia and hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.68 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360609 | — | — | 1 | 6.55 |
| CHEMBL3360608 | — | — | 1 | 6.23 |
| CHEMBL3360607 | — | — | 1 | 6.19 |
| CHEMBL3360603 | — | — | 1 | 6.17 |
| CHEMBL3360612 | — | — | 1 | 6.03 |
| CHEMBL3360604 | — | — | 1 | 5.99 |
| CHEMBL3360610 | — | — | 1 | 5.86 |
| CHEMBL3360618 | — | — | 1 | 5.84 |
| CHEMBL3360605 | — | — | 1 | 5.74 |
| CHEMBL3360602 | — | — | 1 | 5.69 |
| CHEMBL3360613 | — | — | 1 | 5.64 |
| CHEMBL3360619 | — | — | 1 | 5.59 |
| CHEMBL3360616 | — | — | 1 | 5.59 |
| CHEMBL3360617 | — | — | 1 | 5.55 |
| CHEMBL3360620 | — | — | 1 | 5.46 |
| CHEMBL3352899 | — | — | 1 | 5.37 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.36 |
| CHEMBL3360614 | — | — | 1 | 5.30 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.28 |
| CHEMBL3360606 | — | — | 1 | 5.26 |
| CHEMBL3360611 | — | — | 1 | 5.22 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.03 |
| CHEMBL3360615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360609 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3360608 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3360607 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3360603 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3360612 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3360604 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3360610 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3360618 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL3360605 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL3360602 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL3360613 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL3360619 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL3360616 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL3360617 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL3360620 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL3352899 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL3360614 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL939 | GEFITINIB | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL3360606 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL3360611 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL3360615 | — | IC50 | > | 50000.0 | nM | - |