Assay Detail
Binding
CHEMBL3375440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence of 10 uM ATP
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Sgk1 (CHEMBL2343) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356029 | — | — | 1 | 9.00 |
| CHEMBL3092468 | — | — | 1 | 9.00 |
| CHEMBL3092467 | — | — | 1 | 8.70 |
| CHEMBL3356044 | — | — | 1 | 8.70 |
| CHEMBL3356048 | — | — | 1 | 8.70 |
| CHEMBL3356049 | — | — | 1 | 8.70 |
| CHEMBL3356050 | — | — | 1 | 8.70 |
| CHEMBL3356053 | — | — | 1 | 8.70 |
| CHEMBL3092463 | — | — | 1 | 8.70 |
| CHEMBL3092462 | — | — | 1 | 8.70 |
| CHEMBL3356024 | — | — | 1 | 8.70 |
| CHEMBL3356059 | — | — | 1 | 8.70 |
| CHEMBL3092466 | — | — | 1 | 8.70 |
| CHEMBL3092465 | — | — | 1 | 8.52 |
| CHEMBL3356054 | — | — | 1 | 8.52 |
| CHEMBL3356018 | — | — | 1 | 8.52 |
| CHEMBL3356052 | — | — | 1 | 8.52 |
| CHEMBL3092460 | — | — | 1 | 8.52 |
| CHEMBL3356060 | — | — | 1 | 8.52 |
| CHEMBL3356039 | — | — | 1 | 8.40 |
| CHEMBL3092464 | — | — | 1 | 8.40 |
| CHEMBL3092461 | — | — | 1 | 8.30 |
| CHEMBL3356026 | — | — | 1 | 8.22 |
| CHEMBL3356031 | — | — | 1 | 8.05 |
| CHEMBL3356051 | — | — | 1 | 8.00 |
| CHEMBL3356058 | — | — | 1 | 7.89 |
| CHEMBL3356019 | — | — | 1 | 7.85 |
| CHEMBL3356041 | — | — | 1 | 7.85 |
| CHEMBL3356047 | — | — | 1 | 7.82 |
| CHEMBL3356038 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356029 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3092468 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3356044 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3356048 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3356049 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3356050 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3356053 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092463 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092462 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3356024 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3356059 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092466 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092467 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3092460 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3356054 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3356018 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3356052 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3092465 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3356060 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3356039 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3092464 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3092461 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3356026 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3356031 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3356051 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3356058 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3356041 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3356019 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3356047 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3356038 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3356020 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3356042 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3356046 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3356016 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3356061 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3356027 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3356022 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3356040 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL3356015 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL3356045 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL3356057 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL3356055 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL3356056 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL3356014 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3356013 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL3356012 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL3356017 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3356025 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL3356028 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL3356030 | — | IC50 | < | 1.0 | nM | - |