Assay Detail
Binding
CHEMBL3375447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Sgk1 (CHEMBL2343) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.01 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092468 | — | — | 1 | 6.16 |
| CHEMBL3092460 | — | — | 1 | 5.85 |
| CHEMBL3092467 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092468 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3092460 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3092467 | — | IC50 | - | — | - |