Assay Detail
Binding
CHEMBL3375484
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human GnRH receptor expressed in CHO cells by IP-one HTRF assay
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GnRH antagonists: the promise of treating sex-hormone-related diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.54 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358413 | — | — | 2 | 8.48 |
| CHEMBL3358416 | — | — | 2 | 8.26 |
| CHEMBL3358415 | — | — | 2 | 7.17 |
| CHEMBL3358414 | — | — | 2 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358413 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3358416 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3358415 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3358414 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3358414 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL3358413 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL3358415 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL3358416 | — | IC50 | = | 9350.0 | nM | 5.03 |