Assay Detail
Binding
CHEMBL3375499
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Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
9
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.97 | 8.38 |
| Ki | 3 | 8.59 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108438 | — | — | 1 | 8.82 |
| CHEMBL2396664 | — | — | 1 | 8.66 |
| CHEMBL3358422 | — | — | 1 | 8.38 |
| CHEMBL2042018 | — | — | 2 | 8.28 |
| CHEMBL3358423 | — | — | 1 | 8.19 |
| CHEMBL3358424 | — | — | 1 | 8.05 |
| CHEMBL3358420 | — | — | 1 | 7.78 |
| CHEMBL3358421 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108438 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2396664 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL3358422 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL2042018 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL2042018 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3358423 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3358424 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3358420 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL3358421 | — | IC50 | = | 60.6 | nM | 7.22 |