Assay Detail
Binding
CHEMBL3375590
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.45 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3315084 | — | — | 1 | 9.00 |
| CHEMBL3315083 | — | — | 1 | 8.52 |
| CHEMBL3315089 | — | — | 1 | 8.30 |
| CHEMBL3315088 | — | — | 1 | 8.30 |
| CHEMBL3315079 | — | — | 1 | 8.10 |
| CHEMBL3315080 | — | — | 1 | 7.96 |
| CHEMBL3315072 | — | — | 1 | 7.89 |
| CHEMBL3315087 | — | — | 1 | 7.89 |
| CHEMBL3315077 | — | — | 1 | 7.82 |
| CHEMBL3315081 | — | — | 1 | 7.77 |
| CHEMBL3315086 | — | — | 1 | 7.77 |
| CHEMBL48017 | — | — | 1 | 7.77 |
| CHEMBL3315090 | — | — | 1 | 7.70 |
| CHEMBL3315078 | — | — | 1 | 7.35 |
| CHEMBL3315085 | — | — | 1 | 7.21 |
| CHEMBL3315076 | — | — | 1 | 7.20 |
| CHEMBL3313943 | — | — | 1 | 7.09 |
| CHEMBL3315073 | — | — | 1 | 6.96 |
| CHEMBL3315074 | — | — | 1 | 6.67 |
| CHEMBL3315075 | — | — | 1 | 5.70 |
| CHEMBL3315082 | — | — | 1 | 5.42 |
| CHEMBL3315071 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3315084 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3315083 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3315089 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3315088 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3315079 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3315080 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3315072 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3315087 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3315077 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3315081 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3315086 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL48017 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3315090 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3315078 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3315085 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3315076 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3313943 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3315073 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3315074 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL3315075 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL3315082 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL3315071 | — | IC50 | = | 3790.0 | nM | 5.42 |