Assay Detail
Functional
CHEMBL3375734
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Cytotoxicity against human MONO-MAC-6 cells after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MONO-MAC-6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Melleolides induce rapid cell death in human primary monocytes and cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.53 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3120620 | — | — | 1 | 7.52 |
| CHEMBL3311029 | — | — | 1 | 5.54 |
| CHEMBL1078389 | ARNAMIAL | — | 1 | 5.50 |
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | — | 1 | 5.38 |
| CHEMBL1762764 | ARMILLARIDIN | — | 1 | 5.25 |
| CHEMBL1762773 | ARMILLARIN | — | 1 | 5.18 |
| CHEMBL1078142 | MELLEOLIDE D | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3120620 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3311029 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1078389 | ARNAMIAL | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1762764 | ARMILLARIDIN | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1762773 | ARMILLARIN | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1078142 | MELLEOLIDE D | EC50 | = | 48600.0 | nM | 4.31 |