Assay Detail
Binding
CHEMBL3375768
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Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.23 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319223 | — | — | 1 | 8.96 |
| CHEMBL3319215 | — | — | 1 | 8.31 |
| CHEMBL3319405 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319223 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3319215 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3319405 | — | IC50 | = | 39.0 | nM | 7.41 |