Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3375792

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of IL2 production in activated mouse lymphocytes after 3 hrs by ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Lymphocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Lymphocyte (CHEMBL612599)
Type CELL-LINE

Publication

Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors.
Kawai K, Endo Y, Asano T, Amano S, Sawada K, Ueo N, Takahashi N, Sonoda Y, Nagai M, Kamei N, Nagata N.
J Med Chem (2014) 57 : 9844 -9854
PubMed 25383422 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.96 7.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3354181 1 7.11
CHEMBL3354179 1 7.05
CHEMBL3354177 1 6.54
CHEMBL3354169 1 6.25
CHEMBL3354170 1 6.05
CHEMBL3354168 1 6.01
CHEMBL3354173 1 6.00
CHEMBL3354180 1 6.00
CHEMBL3354178 1 5.89
CHEMBL3354171 1 5.89
CHEMBL3354172 1 5.77
CHEMBL3354175 1 5.75
CHEMBL3354174 1 5.70
CHEMBL3354167 1 5.54
CHEMBL3354182 1 5.52
CHEMBL3354160 1 5.27
CHEMBL3354176 1 5.04
CHEMBL3354166 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3354181 IC50 = 77.0 nM 7.11
CHEMBL3354179 IC50 = 89.0 nM 7.05
CHEMBL3354177 IC50 = 290.0 nM 6.54
CHEMBL3354169 IC50 = 560.0 nM 6.25
CHEMBL3354170 IC50 = 890.0 nM 6.05
CHEMBL3354168 IC50 = 980.0 nM 6.01
CHEMBL3354173 IC50 = 1000.0 nM 6.00
CHEMBL3354180 IC50 = 1000.0 nM 6.00
CHEMBL3354178 IC50 = 1300.0 nM 5.89
CHEMBL3354171 IC50 = 1300.0 nM 5.89
CHEMBL3354172 IC50 = 1700.0 nM 5.77
CHEMBL3354175 IC50 = 1800.0 nM 5.75
CHEMBL3354174 IC50 = 2000.0 nM 5.70
CHEMBL3354167 IC50 = 2900.0 nM 5.54
CHEMBL3354182 IC50 = 3000.0 nM 5.52
CHEMBL3354160 IC50 = 5400.0 nM 5.27
CHEMBL3354176 IC50 = 9100.0 nM 5.04
CHEMBL3354166 IC50 > 3000.0 nM -