Assay Detail
Binding
CHEMBL3375807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.09 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354187 | — | — | 1 | 7.92 |
| CHEMBL3354186 | — | — | 1 | 6.66 |
| CHEMBL3354185 | — | — | 1 | 5.87 |
| CHEMBL3354191 | — | — | 1 | 5.78 |
| CHEMBL3354188 | — | — | 1 | 5.70 |
| CHEMBL3354192 | — | — | 1 | 5.65 |
| CHEMBL3354189 | — | — | 1 | 5.64 |
| CHEMBL3352835 | — | — | 1 | 5.48 |
| CHEMBL3354190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354187 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3354186 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3354185 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL3354191 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL3354188 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL3354192 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL3354189 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL3352835 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3354190 | — | IC50 | > | 10000.0 | nM | - |