Assay Detail
Binding
CHEMBL3375808
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Inhibition of CDK2 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.89 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354186 | — | — | 1 | 8.30 |
| CHEMBL3354187 | — | — | 1 | 8.00 |
| CHEMBL3354188 | — | — | 1 | 7.10 |
| CHEMBL3354185 | — | — | 1 | 7.05 |
| CHEMBL3354189 | — | — | 1 | 7.03 |
| CHEMBL3354192 | — | — | 1 | 6.32 |
| CHEMBL3352835 | — | — | 1 | 6.30 |
| CHEMBL3354191 | — | — | 1 | 6.28 |
| CHEMBL3354190 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354186 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3354187 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3354188 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3354185 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3354189 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3354192 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL3352835 | — | IC50 | = | 503.0 | nM | 6.30 |
| CHEMBL3354191 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3354190 | — | IC50 | = | 2220.0 | nM | 5.65 |